Objective To explore the value of cytokines in the early diagnosis and treatment effect evaluation of childhood nonalcoholic fatty liver disease(NAFLD).Methods Serum levels of IL-2,IL-4,IL-6,IL-8,IL-10,TNF-α,as well as biochemical markers,were measured and compared between simple obese children(n=90),children with NAFLD(n=90),and healthy children(n=90).The simple obese children and NAFLD children followed a 6-month lifestyle intervention(dietary advice,exercise requirements),and the aforementioned parameters were compared again.Results Baseline comparisons among the three groups showed significant differences in IL-6 and IL-10(P＜0.05,respectively).In NAFLD group,IL-6 and IL-10 were higher than simple obesity group and the control group(P＜0.05,respectively),while the simple obesity group had higher IL-6 than the control group(P＜0.05).There were no significant differences in IL-2,IL-4,and TNF-α among the three groups(P＞0.05,respectively).Significant differences were observed in BMI,ALT,AST,TG,HDL,UC,INS,and HOMA-IR among the three groups(P＜0.05,respectively).Upon intervention,BMI decreased in the simple obesity group and the NAFLD improvement group compared to pre-intervention(P＜0.05,respectively).In the NAFLD improvement group,IL-6 and IL-10 decreased after the intervention(P＜0.05,respectively),while IL-2,IL-4,and TNF-α showed no significant differences(P＞0.05,respectively).Conclusion Low-grade inflammation is present in children with obesity and NAFLD,and the inflammation in NAFLD patients improve with disease amelioration.Changes in serum IL-6 and IL-10 can occur independently of alterations in glucose and lipid metabolism markers.
万方数据
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