Objective To investigate the clinical features and risk factors of hyperlipidemia pancreatitis(HLP)complicated with diabetic ketoacidosis(DKA).Methods The clinical data of patients with HLP from January 2021 to February 2023 were analyzed retrospectively.According to the presence or absence of DKA,the patients were divided into two groups:hyperlipidemia pancreatitis group(HLP group)and HLP with DKA group(HLP+DKA group).The general clinical data and laboratory data were compared between the two groups.The risk factors of HLP combined with DKA were analyzed by multivariate Logistic regression.Results 24 patients with HLP had DKA(29.6％).Patients with a history of diabetes mellitus were more likely to have DKA(P＜0.001).Compared with HLP group,HLP+DKA group had higher disease severity(P=0.028).In laboratory examination,the fasting blood glucose(P＜0.001),triglyceride(P=0.001),total cholesterol(P＜0.001),high-density lipoprotein cholesterol(P=0.005)and glycated hemoglobin(P＜0.001)were higher in HLP+DKA group.Multivariate Logistic regression analysis showed that history of diabetes(OR=65.566,95％CI:1.425～3016.721,P=0.032)and glycated hemoglobin(OR=2.637,95％CI:1.225～5.678,P=0.013)were independent risk factors for DKA in HLP.According to the receiver operating characteristic(ROC)curve,when glycated hemoglobin 8.85％was the critical value,the sensitivity and specificity of predicting HLP+DKA were 91.3％and 78.9％respectively.Conclusion History of diabetes and increased glycated hemoglobin are independent risk factors for HLP+DKA.Combined DKA can aggravate the severity of HLP.When the glycated hemoglobin is 8.85％,the predictive value of HLP+DKA is the highest.
万方数据
维普
