Objective To analyze the factors associated with the inability to revert preventive ileostomy after anterior resection of rectal cancer.Methods Clinical data were collected from 187 patients with concurrent prophylactic ileostomy after rectal precancerous resection from January 2010 to December 2021,and clinicopathological data and follow-up information were analyzed.Results In this study,187 patients were included in the analysis,among which 32 patients did not complete ileostomy return,and the unretum rate was 17.1%.Univariate analysis showed that the factors related to unretum included history of neoadjuvant radiotherapy and chemotherapy,low rectal tumor,late tumor stage,postoperative anastomotic complications,intestinal obstruction and tumor progression including local recurrence and distant metastasis.Multivariate analysis showed that anastomotic complications,local recurrence or distant metastasis were independent prognostic factors of unreturn of preventive ileostomy after radical resection of rectal cancer(P<0.05).Conclusion For patients with high risk factors of ileostomy,such as postoperative anastomotic complications,advanced tumor before operation or high risk factors of postoperative recurrence or metastasis,the possibility of ileostomy after operation should be fully considered,and the operation and ostomy methods should be carefully selected.