Objective To analyze the risk factors for urinary sepsis after ureteroscopic lithotripsy.Methods From January 2015 to January 2020,139 patients who underwent flexible ureteroscopic lithotripsy in our hospital were divided into the sepsis group(n=13)and non-sepsis group(n= 126)according to whether urinary sepsis occurred after the operation.The clinical routine test indexes before and after the operation were collected,and the risk factors were evaluated by Logistic regression analysis.Results The logistic regression analysis showed that surgery time>120 minutes,stone diameter>16 mm,no use of antibiotics before surgery,preoperative fever,and urinary tract infection were independent risk factors for urinary sepsis after ureteroscopic lithotripsy.Conclusion The surgical time of ureteroscopic lithotripsy should be controlled within 120 minutes as much as possible.For the patients with preoperative fever and preoperative urinary tract infection,they should be given antibiotics as soon as possible.For the patients with stone diameter greater than 16 mm,staged treatment or other treatment options should be chosen.