Objective To investigate the risk factors of hemorrhagic transformation after thrombolysis in acute ischemic stroke.Methods We collected and analyzed the clinical data of patients with acute ischemic stroke who received rt-PA intravenous thrombolysis in the people's Hospital Affiliated to Jiangsu University from 2020 to 2022.They were divided into the hemorrhagic transformation group(40 cases)and the non-hemorrhagic transformation group(223 cases).Multivariate logistic regression was used to analyze the risk factors of hemorrhagic transformation after thrombolysis.Results Multivariate logistic regression analysis showed that high NIHSS score(P<0.01)and high blood glucose(P=0.04)were risk factors for hemorrhagic transformation after thrombolysis.Conclusion High NIHSS score and high blood glucose before thrombolysis are associated with hemorrhagic transformation after intravenous thrombolysis.