Objective To analyze the incidence and related influencing factors of postoperative delirium(POD)in patients with colorectal cancer undergoing radical surgery.Methods A total of 198 patients who underwent radical surgery for colorectal cancer from January 2021 to June 2022 were selected as the research subjects.The postoperative patients were divided into a POD group and a non-POD group by using the consciousness disorder assessment method.The general information,disease characteristics,and surgical data of patients in two groups were compared,and the relevant risk factors for postoperative delirium in patients were analyzed.Results 28 patients experienced postoperative delirium.The age,alcohol consumption,degree of infection,number of laparotomy surgeries,and the use of analgesic pumps in the POD group were all higher than those in the non-POD group,with statistical differences(P<0.05).The education level,physical activity,and nutritional status of patients in the POD group were lower than those in the non-POD group,with statistical differences(P<0.05).The results of multivariate logistic regression analysis showed that insufficient postoperative activity(OR=2.84,P=0.001),infection(OR=2.16,P=0.01),and poor nutritional status(OR=1.3,P=0.02)were independent influencing factors for the occurrence of POD.Conclusion In order to prevent and reduce the occurrence of POD in colorectal cancer patients,it is necessary to require patients to exercise appropriately before surgery,get out of bed as soon as possible after surgery,regularly monitor infection indicators and nutritional status,and adjust clinical treatment and nursing education plans in a timely manner.