Objective To test the reliability and validity of the Chinese version of the 8-item Morisky Medication Adherence Scale(MMAS-8)in patients with acute herpetic zoster neuralgia.Methods 160 patients with acute herpetic zoster neuralgia were investigated with a convenient sampling method to evaluate the reliability and validity of the scale.Results The critical ratio method was used to analyze the items,and it was found that the T-test difference between the top 27%high group and the bottom 27%low group on 8 items was statistically significant(P<0.001).The overall Cronbach'sα coefficient was 0.783,and the standardized Cronbach'sα coefficient was 0.808.Structural validity(KMO value 0.801 and Bartlett's spherical test value 393.895).Two common factors were extracted by exploratory factor analysis,which could explain 61.055%of the total variance.The results of confirmatory factor analysis showed that the Chi-square freedom ratio of the modified model was 1.262,the goodness of fit index(GFI)was 0.969,the adjusted goodness of fit index(AGFI)was 0.934,the comparative goodness of fit index(CFI)was 0.989,and the root mean square error(RMSEA)was 0.042.Conclusion The Chinese version of MMAS-8 has good reliability and validity,and can be used as an evaluation tool for medication compliance in patients with acute herpetic zoster neuralgia.