Objective To investigate the changes in testosterone levels,aggression,creativity,visuospatial perception and selective attention in male adolescents with schizotypal personality disorder.And to analyze the relationship between testosterone levels and SPQ,aggression,creativity,visuospatial perception,and selective attention.Methods MMPI-566(Minnesota Multiphasic Personality Inventory)was used to screen out schizophrenia(Sc)from 3,500 male freshmen of Maritime University.The criteria of Schizotypal personality disorder(SPD)were SC>70,65<F<79,SPD received by two psychiatrist with interview structural DSM-IV for Schizotypal personality disorder.50 SPD met the criteria of DSM-IV diagnosis served as the study group,and randomly draw out 50 normal personality students as the control group.All subjects received self-made general questionnaire,Aggression questionnaire,Williams Prefer Measurement Forms and Schizotypal personality questionnaire(SPQ).The line segment direction judgment test evaluated visual spatial perception,and the Stroop color word interference test evaluated partial executive function.D2:D4 ratio was used to assess prenatal exposure levels to testosterone.Testosterone of serum were measured by Electrochemiluminescence method.Results There were significant differences between the SPD group and the control group(P<0.05)in testosterone levels.There were significant differences between the SPD group and the control group in the right 2D:4Dratio(P<0.05).In the SPD group,testosterone levels significantly positively correlated with odd beliefs in SPQ(P<0.05).In the Aggression Questionnaire,the total score and physical aggression,anger,and hostility factors of the two groups were compared,and the difference in score values was statistically significant(P<0.05).In the Williams Creativity Scale,there was a statistically significant difference in total score and imagination factor score between the two groups(P<0.05).There were statistically significant differences in the scores,total scores,and three main dimensions of the split personality questionnaire(SPQ)between the two groups(P<0.05).The results of the line segment direction judgment test showed that the correct number score of the split personality disorder group was higher than that of the control group,and the difference in score was statistically significant(P<0.05).The Stroop Test showed that under four different Stroop word color interference conditions,there was no statistically significant difference in the correct number scores and various stimulus response times between the split personality disorder group and the control group.Conclusion Male adolescents have higher levels of SPD testosterone.Testosterone levels are negatively correlated with BMI,and positively correlate with curiosity factor,total creativity score,and positive split type symptoms.Testosterone is a risk factor for SPD and Sc(schizophrenia ruler).Odd belief symptom may be is early behavior mark for Sc or SPD.
Schizotypal personality disorderTestosteroneVisual spatial perceptionStroop test
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