Objective To investigate the diagnostic value of pepsinogen Ⅰ(PG-Ⅰ),pepsinogen Ⅱ(PG Ⅱ),PG-Ⅰ/PG Ⅱ and gastrin(G-17)levels in the development and prognosis of gastric ulcer.Methods 99 patients with gastric ulcer admitted to Tongxiang Fourth People's Hospital from January 2020 to December 2022 were selected as the study objects.According to Teratada's staging criteria,they were divided into the active group(n=33,active stage),the healing group(n=33,healing stage)and the scar group(n=33,scar stage).The expression levels of PG Ⅰ,PG Ⅱ,PG Ⅰ/PG Ⅱ and G-17 were measured by automatic chemiluminescence immunoassay.The differences of 4 indexes among the three groups and 99 patients before and after treatment were compared,and the application value of 4 indexes in the staging and prognosis of gastric ulcer was discussed.Results The proportion of abdominal pain,loss of appetit e,belching,distension,nausea and vomiting,VAS score,PG Ⅱ value and G-17 value in the active group were higher than those in the healing group and scar group(P<0.05).The PG-Ⅰ and PG-Ⅰ/PG Ⅱ values in the active group were lower than those in the healing group and scar group(P<0.05).PG Ⅰ,PG-Ⅰ/PG Ⅱ were negatively correlated with VAS scores(r=-0.631,-0.611).PG Ⅱ and G-17 were positively correlated with VAS scores(r=0.724,0.706)(P<0.05).The area under the curve AUC(0.869)of PG Ⅰ,PG Ⅱ,PG Ⅰ/PG Ⅱ and G-17 combined diagnosis of gastric ulcer stage was higher than that of single index(P<0.05).After 4 weeks of treatment,the VAS score,PG-Ⅱ value and G-17 value of the good prognosis group were lower than those of the poor prognosis group,and the PG-Ⅰ and PG-Ⅰ/PG-Ⅱ values of the good prognosis group were higher than those of the poor prognosis group(P<0.05).The area under the curve AUC of PG Ⅰ,PG Ⅱ,PG Ⅰ/PG Ⅱ and G-17 combined diagnosis of poor prognosis of gastric ulcer was higher(0.889)than that of single index(P<0.05).Conclusion The expression of PG Ⅰ and PG Ⅰ/PG Ⅱ is low in the active stage and poor prognosis of gastric ulcer,while the expression of PG Ⅱ and G-17 is high in the active stage and poor prognosis of gastric ulcer.The detection of four indicators in patients with gastric ulcer can provide an important reference for the diagnosis of the disease and prognosis.
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