Objective To explore the correlation of serum sulfonylurea receptor 1(Sur 1)with the degree of cerebral edema and prognosis in patients with severe craniocerebral injury.Methods Serum Sur1 concentrations were measured in 100 healthy controls and 96 patients with severe TBI.Samples were retrieved at 12,24,48,72 h after the patient was injured.The degree of cerebral edema was evaluated by head CT and intracranial pressure,and the prognosis was evaluated by the Glass coma score.Three months after trauma,the Glass prognosis score of 1-3 was classified as poor.Results The serum Sur1 concentration in patients was significantly higher than that in control group.Head CT showed that the mean and peak Sur1 concentration were higher in patients with cerebral edema.In 91.7%(88 cases)of intracranial hypertension patients,there was a delay between peak Sur1 concentration and peak ICP.The peak serum Sur1 concentration in patients with poor prognosis was significantly higher than that in patients with good prognosis.Conclusion Rising serum Sur1 concentrations are highly correlated with cerebral edema and are independently associated with poor prognosis after TBI,indicating that serum Sur1 may have the potential to be a useful prognostic biomarker of TBI.
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