Objective To explore the correlation between the levels of serum interferon regulatory factor 5(IRF 5)and Mucin 1(MUC 1)and the intestinal flora and the severity of gastrointestinal symptoms in patients with irritable bowel syndrome(IBS),in order to provide new biological indicators for the clinical study of IBS.Methods A total of 120 IBS patients admitted to our hospital from January 2022 to January 2023 were regarded as the IBS group,according to the diagnostic criteria of IBS,64 cases of constipation type(IBS-C)were classified as the IBS-C group,and 56 cases of diarrhea type(IBS-D)were classified as the IBS-D group.Sixty healthy volunteers who underwent physical examination in our hospital were regarded as the control group.The correlation between IRF 5 and MUC 1 levels and IBS symptom severity scale(IBS-SSS)score was explored by Pearson correlation analysis.Results The expression level of IRF 5 and the numbers of Prevotella and Bifidobacterium in the serum of patients in the IBS-D group were obviously lower than those in the IBS-C group and the control group,while the IBS-C group were obviously lower than the control group,the expression level of MUC 1,the numbers of Enterococcus and Escherichia coli in the IBS-D group were obviously higher than those in the IBS-C group and the control group,and the IBS-C group were obviously higher than those in the control group(P<0.05).Compared with the IBS-C group,the IBS-D group showed a obvious increase in the IBS-SSS score(P<0.05).Conclusion The serum IRF 5 expression in IBS patients is low,while MUC 1 expression is high,the two have a certain correlation with intestinal microbiota and the severity of gastrointestinal symptoms.
万方数据
维普
