Objective To investigate the prognostic value of triglyceride glucose(TyG)index in postmenopausal women with acute coronary syndrome(ACS)undergoing percutaneous coronary intervention(PCI).Methods A total of 313 postmenopausal women with ACS undergoing PCI were enrolled in this study.According to the occurrence of major cardiovascular adverse events(MACE),the two groups were divided into the non-MACE group and the MACE group,and the four groups were divided into T1,T2,T3 and T4 groups according to the quartiles of TyG index.To evaluate the effect of TyG index on the long term prognosis of postmenopausal women with ACS undergoing PCI.Multivariate COX regression was used to analyze the factors affecting the adverse prognosis,and the Kaplan-Meier curve was used to compare the survival among TyG groups.Results During a median follow-up of 4 years,112(35.8%)patients had MACE events.Multivariate COX regression analysis showed that triglyceride glucose index was an independent predictor of MACE(HR=1.428,95%CI:1.031~1.979,P=0.032).Kaplan-Meier curve and log-rank analysis showed that there were significant differences in survival rate among different TyG groups(P=0.034),and the survival rate decreased with the increase of TyG index.Conclusion Triglyceride glucose index has a certain predictive value for the long term prognosis of postmenopausal women with ACS undergoing PCI.