Objective To investigate the clinical efficacy of percutaneous vertebroplasty(PVP)combined with spinal reduction(position reduction combined with manual reduction)and percutaneous kyphoplasty(PKP)in the treatment of fresh osteoporotic vertebral compression fracture(OVCF).Methods Retrospective analysis of 120 OVCF patients admitted from June 2020 to June 2022,2 years,divided into two groups,60 cases,comparing the operation time,the amount of intraoperative bleeding,postoperative cement leakage,postoperative hospitalization days,postoperative pain and life ability improvement(VAS score and Barthel index at 1 day,1 month and 3 months).Results The operation time of PVP combined with ridge reduction was shorter than the PKP group,the difference was statistically significant(P<0.01).The intraoperative blood loss,postoperative cement leakage and postoperative hospitalization days were comparable between the two groups,there was no significant difference(P>0.05).The postoperative pain and average living ability improved significantly in both groups,statistically significant comparison before surgery(P<0.01).However,in the postoperative comparison between the two groups,there was no significant difference(P>0.05).PVP combined with ridge reduction and PKP group can restore the vertebral height.The recovery height recovery was better in the postoperative PKP group,the difference was significant(P<0.01).Conclusion Both methods of fresh single-segment OVCF can provide good short-term and medium-term analgesia and activity of patients.PVP combined with ridge reduction is simpler,operation time is shorter.PKP is slightly better than PVP combined with spine reduction.Both have different advantages.Therefore,the two surgical options should be selected according to the patient's situation.