Objective To observe the clinical efficacy of ginger moxibustion on depression with mild to moderate deficiency syndrome and its influence on serum 5-hydroxytryptamine(5-HT),IL-6 and TNF-α levels.Methods Eighty patients with mild to moderate deficiency depression who were treated in our hospital were randomly divided into two groups according to the generated random numbers.Patients in the treatment group were treated with ginger moxibustion,patients in the control group were treated with repetitive transcranial magnetic stimulation(rTMS).Both groups were treated for 6 weeks.The scores of Hamilton depression scale 17(HAMD-17)and TCM Syndrome Symptom Scale(TSSS)before treatment,2 weeks,4 weeks and 6 weeks after treatment,and the levels of serum 5-HT,IL-6 and TNF-α before and after treatment were compared between the two groups.The HAMD-17 score and TSSS score reduction rate were used to evaluate the efficacy.Results There was no significant difference in HAMD-17 score,TSSS score and serum 5-HT,IL-6 and TNF-α levels between the two groups before treatment(P>0.05).After 2 weeks,4 weeks and 6 weeks of treatment,the HAMD-17 score and TSSS score were lower than those before treatment(P<0.01).After 2 weeks,4 weeks and 6 weeks of treatment,the HAMD-17 score and TSSS score of the treatment group were better than those of the control group(P<0.05).After 6 weeks of treatment,the levels of serum 5-HT in the two groups were higher than those before treatment(P<0.01),and the levels of IL-6 and TNF-α were lower than those before treatment(P<0.01).After 6 weeks of treatment,the changes of serum 5-HT,IL-6 and TNF-α levels in the treatment group were more significant than those in the control group(P<0.05).After 6 weeks,the total effective rate of the treatment group was 86.49%(32/37),and the total effective rate of the control group was 65.71%(23/35).The curative effect of the treatment group was better than that of the control group(P<0.05).Conclusion Ginger moxibustion has a good effect in the treatment of mild to moderate deficiency depression,and its efficacy is comparable to that of rTMS,but it is better than rTMS in the early treatment of mild to moderate depression.Ginger moxibustion can increase serum 5-HT and reduce IL-6 and TNF-α levels in patients with depression.
万方数据
维普
