Objective To investigate the risk factors for renal damage associated with hyperuricemia(HUA).Methods The clinical data of 132 patients with HUA admitted to our hospital from April 2021 to March 2023 were retrospectively analyzed,and they were divided into the kidney injury group(54 cases)and the normal kidney function group(78 cases)according to whether they had renal injury.The clinical data of the two groups were compared,the factors of kidney injury was analyzed,receiver operating characteristic curve(ROC)was used to analyze the predictive value,and Pearson correlation was used to analyze the correlation between clinical index and kidney injury indicators.Results The levels of disease course,systolic blood pressure,triglycerides(TG),low density lipoprotein cholesterol(LDL-C),serum uric acid(SUA),urea nitrogen(BUN)and serum creatinine(Scr)in the kidney injury group were significantly higher than those in the normal kidney function group(P<0.05),glomerular filtration rate(eGFR)level was significantly lower than that of normal kidney function group(P<0.05).Logistic regression analysis showed that disease course,systolic blood pressure,TG,LDL-C and SUA were the main factors affecting kidney injury in hyperuricemia patients(P<0.05).ROC curve analysis results showed that the AUC of disease course,systolic blood pressure,TG,LDL-C and SUA were 0.596,0.545,0.746,0.651 and 0.724,respectively.Pearson correlation analysis showed that disease course,systolic blood pressure,TG,LDL-C,SUA were positively correlated with Scr,was negatively correlated with eGFR.Conclusion Disease course,blood pressure,SUA,LDL-C and TG are significantly correlated with kidney injury in HUA patients,and monitoring their levels is helpful for early screening of kidney injury.
HyperuricemiaUric acidLow density lipoprotein cholesterolTriglycerideKidney injury
万方数据
维普
