Objective To explore the current situation and related factors of adverse events of transfusion of cryopreserved autologous hematopoietic stem cells,and provide reference for clinical practice.Methods Using the convenient sampling method,224 patients who underwent autologous hematopoietic stem cell transplantation in the blood transplantation center of a third-class hospital in Wenzhou City from September 2019 to September 2022 were selected as the study subjects.The data were collected using the general data questionnaire and the adverse events questionnaire of autologous hematopoietic stem cell infusion,and the current situation of adverse events of autologous stem cell infusion in deep hypothermia was summarized and the influencing factors were analyzed.Results The total incidence of adverse events of transfusion of cryopreserved autologous hematopoietic stem cells was 72.3%.The system organ with the highest incidence rate was gastrointestinal diseases,accounting for 33.3%,followed by respiratory,thoracic and mediastinal diseases,accounting for 30.9%.The severity is mostly level 1,accounting for 68%.The risk factors causing adverse events were age,transfusion volume,previous blood transfusion history and other diseases.Conclusion The incidence of adverse events of transfusion of cryopreserved autologous hematopoietic stem cells is high,but most of them are mild.During the peri-infusion period,clinical medical staff should pay attention to the infusion rate,strengthen monitoring and provide predictive nursing measures for the elderly patients with large infusion volume,history of blood transfusion and other diseases to ensure the safety of patients.
维普
万方数据
