Objective To explore the value of magnetic susceptibility-weighted imaging(SWI)in the diagnosis of superficial siderosis of the central nervous system(SSCNS).Methods 43 cases of SSCNS(including 29 cases of cSS and 14 cases of iSS)who received routine T2WI,DWI and SWI were collected to analyze the MRI performance,and compare the statistical differences of detection rate of lesions on SWI,T2WI and DWI sequences of two subtypes of cSS and iSS.Results For the 43 cases of SSCNS,the all number of lesions was 264,including 29 cases of cSS with 79 lesions and 14 cases of iSS with 185 lesions.The detection rate of T2WI,DWI and SWI was 47.7%,60.6%and 100.0%.The detection rate of cSS lesions was 39.2%,50.6%and 100.0%,and the detection rate of iSS lesions was 51.4%,64.9%and 100.0%.There was no significant difference between DWI and T2WI in the detection rate of cSS(P>0.05),there was significant difference in the detection rate of iSS and SSCNS(P<0.05).There were statistically significant differences between SWI and the other two sequences in the detection rate of SSCNS and two subtypes(P<0.05).Conclusion SWI is more senstive to diagnosis SSCNS than T2WI and DWI,and it is helpful for the early and comprehensive evaluation of iron deposition and distribution range,and SWI should be used as a routine examination sequence for diagnose of SSCNS.