Objective To investigate the significance of the expression of calmodulin 17(CDH17)in gastric cancer and its differentiation value from adenocarcinoma in other sites.Methods 319 cases of primary adenocarcinomas of digestive system origin in the last 5 years were collected,including 114 cases of gastric cancer,150 cases of colorectal cancer,55 cases of pancreaticobiliary cancer,and 29 cases of primary adenocarcinomas of non-digestive system origin.The expression levels of CDH17 and tail-type homology cassette transcription factor-2(CDX2)in different adenocarcinomas were detected by immunohistochemical methods.Results Gastric mucosal epithelial cells in which intestinal epithelial hyperplasia occurred showed positive expression of CDH17.The positive expression rates of CDH17 and CDX2 in adenocarcinoma in each group were 74.6%(85/114)and 79.8%in gastric cancer;95.3%and 98.7%in colorectal cancer;34.5%and 21.8%in pancreatico-biliary cancer,and the expression was not seen in non-digestive adenocarcinoma,respectively,the differences of CDH17 and CDX2 were statistically significant among all groups(P<0.001).The expression of CDH17 and CDX2 was positively correlated in gastric,colorectal and pancreaticobiliary cancers(P<0.001).The positive expression rate was 88.6%in gastric cancer by the combined detection of CDH17 and CDX2 with positive result of either marker as positive result,which increased the sensitivity by 14%and 8.8%compared with the single-marker detection;the expression rate of both markers negative in pancreaticobiliary carcinoma was 60%,and the combined detection of CDH17 and CDX2 The results were statistically significant in gastric cancer and pancreaticobiliary cancer(P<0.001).The expression level of CDH17 in gastric cancer was correlated with Lauren staging(P<0.05),but not with tumour size,T stage,vascular nerve invasion,lymph node or distant metastasis.Conclusion CDX2 is currently a more specific marker for tumours of the digestive system,but its expression is relatively low in gastric cancer,and a small amount in pancreaticobiliary carcinoma.CDH17 is highly expressed in gastric cancer,and its expression level correlates with the Lauren typing bowel phenotype of gastric cancer.Positive expression of CDH17 is lower than that of colorectal cancer in gastric cancer but significantly higher than that of pancreaticobiliary carcinoma and non-digestive adenocarcinomas.CDH17 can be used as a a novel marker for the digestive system,and in combination with CDX2 detection,it can help to determine the tissue origin of adenocarcinoma of the digestive system.
万方数据
维普
