Objective To investigate the application value of two-dimensional speckle tracking imaging(2D-STI)combined with serum creatine kinase(CK)in monitoring cardiotoxicity after anthracycline chemotherapy for breast cancer.Methods 102 breast cancer patients who underwent anthracycline chemotherapy in the hospital between February 2021 and February 2023 were selected.After the end of chemotherapy,patients enrolled were divided into the normal group(72 cases)and the abnormal group(30 cases)according to whether the electrocardiogram was normal or not.Meanwhile,34 healthy women were selected as the healthy group.Serum CK was detected,and 2D-STI was performed before and after chemotherapy.The left ventricular strain parameters global longitudinal strain(GLS)were recorded.Results After chemotherapy,serum CK level of the abnormal group was higher than that of the normal group(P<0.05).The GLS of the abnormal group were lower than those of the normal group(P<0.05).The sensitivity and specificity of serum CK to evaluate cardiotoxicity after chemotherapy were 76.67%and 83.33%.The sensitivity and specificity of GLS to evaluate cardiotoxicity after chemotherapy were 83.33%and 72.22%.The sensitivity of joint detection was 96.67%and the specificity was 70.83%.The results of ROC curve analysis showed that the AUC values of GLS,serum CK and their combination in detecting cardiotoxicity after chemotherapy were 0.835,0.820 and 0.895,respectively.Conclusion 2D-STI combined with serum CK is of great value in monitoring cardiotoxicity after anthracycline chemotherapy for breast cancer.Cardiotoxicity after chemotherapy will cause increase in serum CK level and abnormality of left ventricular myocardial strain.
Breast cancerAnthracyclineChemotherapyCardiotoxicityTwo-dimensional speckle tracking imagingCreatine kinase
万方数据
维普
