Objective To analyze the clinical value of CD4+/CD8+ratio and neutrophil CD64 in non-small cell lung cancer(NSCLC).Methods 94 NSCLC patients admitted to our hospital from October 2022 to September 2023 were selected as the study subjects,and 94 healthy individuals who underwent physical examinations at the same time were selected as the control group.Both groups were tested and calculated for CD4+/CD8+ratio and neutrophil CD64 index.The CD4+/CD8+ratio and neutrophil CD64 index were compared between the two groups,and the diagnostic value of CD4+/CD8+ratio and neutrophil CD64 index for NSCLC was evaluated.The relationship between the above indicators and the clinical and pathological characteristics of NSCLC patients was analyzed;According to the treatment effect,patients were divided into objective effective group and non objective effective group,and the CD4+/CD8+ratio and neutrophil CD64 index were compared between the two groups.Result The CD4+/CD8+ratio in the NSCLC group was lower than that in the control group(P<0.05),and the neutrophil CD64 index was higher than that in the control group(P<0.05).The receiver operating curve(ROC)analysis results showed that the AUC values of CD4+/CD8+ratio and neutrophil CD64 index for diagnosing NSCLC were 0.730 and 0.769,respectively,with sensitivity of 71.28％and 64.89％,specificity of 68.09％and 73.40％.The CD4+/CD8+ratio in patients with TNM stages Ⅲ-Ⅳ and lymph node metastasis was lower than that in patients with TNM stages Ⅰ-Ⅱ and no lymph node metastasis(P<0.05).Patients with a maximum tumor diameter of>3 cm,TNM stages Ⅲ-Ⅳ,and lymph node metastasis had a higher neutrophil CD64 index than patients with a maximum tumor diameter of≤3 cm,TNM stages Ⅰ-Ⅱ,and no lymph node metastasis(P<0.05).The CD4+/CD8+ratio in the objective ly effective group was higher than that in the non objective ly effective group(P<0.05),and the neutrophil CD64 index was lower than that in the non objective ly effective group(P<0.05).Conclusion The CD4+/CD8+ratio is low in NSCLC patients,while the neutrophil CD64 index is high,and it is correlated with clinical pathological characteristics and therapeutic efficacy,which can be used as an indicator for evaluating patient condition and treatment effectiveness.
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