Objective To determine the liver shear wave velocity in patients with chronic hepatitis B by using the acoustic-tactile tissue quantification(VTQ)technique with multiple liver segments,and to explore the value of the VTQ technique with multiple liver segments in the diagnosis of liver fibrosis.Methods 94 patients with chronic hepatitis B who underwent VTQ and hepatic puncture biopsy in our hospital were selected to measure the hepatic shear wave velocity(SWV)in the lower right anterior lobe of the liver(S5),the lower right posterior lobe of the liver(S6),and the upper right anterior lobe of the liver(S8).The SWV maxima and minima of each of these patients'three hepatic segments were used to calculate the index of maximum difference between SWVs of each patient.The maximum difference index(DI)of SWV between the liver segments of each patient was calculated based on the maximum SWV(SWVmax)and the minimum SWV(SWVmin)of the three liver segments measured in each patient,and the liver puncture biopsies of the liver segments of each patient were taken.The difference of SWV between liver segments and the correlation of SWV between liver segments of each patient were compared,and the correlation between liver SWV and its pathological results were analyzed.94 patients were divided into two groups,Group 1 patients with consistent SWV in all liver segments(DI<20%),and Group 2 patients with incongruent SWV in all liver segments(DI>20%),and the SWV values of the SWVmax and SWVmin liver segments in the two groups and the pathological results were respectively were compared and analyzed.Results The LSD-t test showed that the difference in SWV measurements of liver S5,S6 and S8 segments was not statistically significant(P>0.05).The results of correlation test showed significant correlation between hepatic S5 and S6,S5 and S8,and S6 and S8(P<0.01).The results of ANOVA showed that there was a significant difference between the SWV values of the five stages(P<0.05),and the SWV values increased with the aggravation of liver fibrosis.There was no statistically significant difference in SWV values and pathologic results between SWVmax and SWVmin liver segments in Group 1 patients(P>0.05),and there was a difference in SWV values and pathologic results between SWVmax and SWVmin liver segments in Group 2 patients(P<0.05).Conclusion The multi-segmental valuation method of VTQ technique has a certain value in the comprehensive assessment of the degree of hepatic fibrosis in chronic hepatitis B patients.
Acoustic palpation tissue quantification techniqueLiver hardnessChronic hepatitis B
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