前列腺癌中Claudin-4和MMP-9表达及其临床意义
胡俊彪 1张春霆 1吴慧玲1
作者信息
摘要
目的 检测前列腺癌中紧密连接蛋白-4(Claudin-4)和基质金属蛋白酶-9(MMP-9)蛋白的表达,探讨Claudin-4和MMP-9蛋白表达与前列腺癌临床预后的相关性.方法 采用组织微阵列和免疫组化SP法检测85例前列腺癌和41例前列腺增生组织中Claudin-4和MMP-9蛋白表达,分析其与临床病理及5年生化复发率和总体生存率的相关性.结果 前列腺癌中Claudin-4和MMP-9蛋白表达阳性率分别为64.56%和58.23%;前列腺增生中表达阳性率分别为33.33%和20.00%,两者比较差异有统计学意义(P<0.05);Claudin-4和MMP-9蛋白表达与前列腺癌TNM分期、Gleason评分、术前PSA、阳性切缘和5年生化复发率和总体生存率有关(P<0.05).Pearson相关性分析显示,前列腺癌中Claudin-4和MMP-9蛋白表达呈正相关(P<0.05).Kaplan-Meier分析显示,Claudin-4和MMP-9蛋白表达增高组前列腺癌5年生化复发和总体生存高于对照组(P<0.05).结论 Claudin-4和MMP-9蛋白在前列腺癌中呈高表达与前列腺癌的发生和发展有关.
Abstract
Objective To detect the expression of Claudin-4(Claudin-4)and Matrix metalloproteinase-9(MMP-9)in prostate cancer,and to explore the relationship between the expression of Claudin-4 and MMP-9 in prostate cancer with clinical prognosis of cancer.Methods The expression of Claudin-4 and MMP-9 proteins was detected in 85 cases of prostate cancer and 41 cases of prostate hyperplasia using tissue microarray and immunohistochemical methods,and their correlation with clinical pathology,5-year biochemical recurrence rate,and overall survival rate was analyzed.Results The positive rates of Claudin-4 and MMP-9 protein expression in prostate cancer were 64.56%and 58.23%.The positive rates in benign prostatic hyperplasia were 33.33%and 20.00%,respectively,and there was a significant difference(P<0.05).Claudin-4 and MMP-9 protein expression correlated with prostate cancer TNM staging and Gleason score,preoperative PSA,positive resection margin,5-year biochemical recurrence rate and overall survival rate(P<0.05).Pearson correlation analysis showed a positive correlation between Claudin-4 and MMP-9 protein expression in prostate cancer(P<0.05).Kaplan-Meier analysis showed that the increased expression of Claudin-4 and MMP-9 protein were higher than those in the control group about the 5-year biochemical recurrence and overall survival of prostate cancer(P<0.05).Conclusion The high expression of Claudin-4 and MMP-9 protein in prostate cancer is related to the occurrence and development of prostate cancer.
关键词
紧密连接蛋白-4/基质金属蛋白酶-9/前列腺肿瘤/组织微阵列/免疫组织化学Key words
Claudin-4/Matrix metalloproteinase-9/Prostate tumor/Tissue microarray/Immunohistochemistry引用本文复制引用
基金项目
浙江省基础公益研究计划项目(LGF20H050002)
浙江省金华市重大科学技术研究计划项目(2021-3-027)
出版年
2024
NETL
NSTL
万方数据