Objective To explore the efficacy of repeated transcranial magnetic stimulation(rTMS)at different high frequency in Parkinson's disease with swallowing disorder.Methods Sixty patients were randomly divided into treatment Group A and Group B.Both groups underwent treatment cycles at intervals of 4 weeks after admission.In the first cycle,Group A received 10Hz rTMS intervention,while Group B received 5Hz rTMS treatment.In the second cycle,neither Group A nor Group B received rTMS intervention.In the third cycle,Group A received 5Hz rTMS intervention,and Group B received 10Hz rTMS intervention.The patients in both groups were evaluated for VFSS scores,SWAL-QOL scores at admission,4 weeks,8 weeks,and 12 weeks later,and AEMG for swallowing 5 mL of water at admission and after 4 weeks.Results After the first cycle of treatment,both groups showed significant improvement in VFSS scores,SWAL-QOL scores,AEMG for swallowing 5 mL of water,and swallowing time compared to before treatment(P<0.01).Group A showed significantly greater improvement in SWAL-QOL scores,AEMG for swallowing 5 mL of water,and swallowing time compared to Group B(P<0.01).In the washout period after the second cycle,Group B had statistically significant differences in VFSS and SWAL-QOL scores before the first and third cycles of treatment(P<0.01),while Group A had no statistically significant differences in VFSS and SWAL-QOL scores before the first and third cycles of treatment(P>0.05).Pairwise analysis of VFSS scores and SWAL-QOL scores for Group A after the first and third cycles of treatment showed that the improvement was more significant after 10Hz treatment compared to 5Hz treatment(P<0.05).After three sequential treatment cycles at different frequencies for Groups A and B,both groups showed significant improvement in VFSS and SWAL-QOL scores after treatment(P<0.01).There was a statistically significant difference in VFSS scores between the two groups(P<0.01),but no statistically significant difference in SWAL-QOL scores(P>0.05).Conclusion Different high-frequency rTMS treatments for Parkinson's disease with swallowing disorders are all significantly effective,improving patients'swallowing function,swallowing muscle tension,and swallowing time,thus enhancing the patients'quality of life.Among them,10Hz high-frequency rTMS has a more significant effect,while 5Hz high-frequency rTMS has a longer-lasting effect and is worthy of clinical application and promotion.
Repetitive transcranial magnetic stimulationParkinson's disease with swallowing disordersCrossover trialRandomized controlled tria
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