目的 评价红蓝光联合治疗慢性伤口的效果。方法 检索PubMed、Embase、Web of Science、Cochrane Library、中国知网、万方、维普、中国生物医学文献数据库(CBM)中关于红蓝光联合辅助慢性伤口治疗的文献，检索时限为2012年1月至2022年7月。由2名研究者独立进行文献筛选、资料提取和质量评价，采用RevMan 5。4软件进行统计分析。结果 共纳入10篇文献，累计样本量为710例，Meta分析结果显示:观察组伤口痊愈率高于对照组[OR=2。03，95%CI(1。33～3。11)，P=0。001]，肉芽组织分级高于对照组[MD=0。95，95%CI(0。18，1。73)，P=0。02]，创面面积缩小率高于对照组[MD=14。43，95%CI(10。98～17。87)，P<0。001]，伤口愈合时间低于对照组[MD=-7。16，95%CI(-8。56～-5。74)，P<0。001]，换药次数低于对照组[MD=-5。44，95%CI(-5。94～-4。95)，P<0。001]，观察组与对照组伤口附近皮肤评分差异无统计学意义[MD=0。10，95%CI(-0。93～1。12)，P=0。85]。结论 红蓝光联合使用治疗慢性伤口能有效提高伤口痊愈率、肉芽组织分级及创面面积缩小率，同时能缩短伤口愈合时间，减少换药次，且对伤口附近皮肤无影响。
Objective To evaluate the effect of red and blue light-supplemented in the treatment of chronic wound.Methods PubMed,Embase,Web of Science,The Cochrane Library,CNKI,Wanfang,VIP,and CBM were searched for literature on combined red and blue light-assisted in the treatment of chronic wound.The search was limited to the period from January 1 to July 31,2012.Literature screening,data extraction,and quality assessment were performed independently by 2 researchers and statistically analyzed using RevMan 5.4 software.Results A total of 10 publications with a total sample size of 710 cases were included,and the Meta-analysis showed that the wound healing rate was higher in the intervention group than in the control group[OR=2.03,95%CI(1.33,3.11),P=0.001],the granulation tissue grading was higher than in the control group[MD=0.95,95%CI(0.18,1.73),P=0.02],and the wound healing time was lower than that of the control group[MD=-7.16,95%CI(-8.56,-5.74),P=0.85].Conclusion The combined use of red and blue light in the treatment of chronic wounds can effectively increase the rate of wound healing,granulation tissue grading and wound reduction,shortening the wound healing time,reducing the number of dressing changes,and has no effect on the skin near the wound.
Red and blue lightWound treatmentEffectMeta-analysis
NETL
NSTL
万方数据
