Objective To investigate the feasibility and safety of implementing same-day discharge for transxiphoid thoracoscopic anterior mediastinal tumor resection.Methods From January to December 2021,all patients who underwent thoracoscopic mediastinal tumor resection at our center were screened.Eligible patients were categorized into two groups based on their length of hospitalization:the same-day mediastinal tumor resection group and the inpatient mediastinal tumor resection group.The clinical indicators including postoperative hospitalization duration,total hospitalization expenses,7-day postoperative readmission rates,the number of emergency department visits,and postoperative complication rates between these two groups were compared.Results The same-day discharge group had a median hospital stay of 21(18.5,22.5)h,whereas the inpatient group had a median stay of 59.5(55.0,69.5)h.The difference in length of stay between the two groups was statistically significant(P<0.001).The incidence of postoperative pulmonary infection in the inpatient group was notably higher compared to the same-day discharge group,although the difference was not statistically significant(P=0.481).Similarly,the rates of re-hospitalization and emergency department visits were higher in the inpatient group than same-day discharge group,but these differences did not reach statistical significance(P>0.05).There were no discernible differences in the incidence of postoperative complications between the two groups(P>0.05).In summary,while the inpatient group exhibited higher rates of rehospitalization and emergency room visits compared to the same-day discharge group,these differences did not achieve statistical significance(P>0.05).Conclusion The daytime surgical management mode is safe and feasible in anterior mediastinal tumor resection while reducing patient medical burden.