Objective To explore the expression levels of microrna-124(miR-124)and microrna-221(mir-224)in peripheral blood of patients with Parkinson's disease(PD)in different treatment periods,and analyze their correlation with non-motor symptoms,so as to provide potential intervention targets for the monitoring and treatment of non-motor symptoms in clinical PD patients.Methods 106 PD patients who were treated in our hospital from January 2020 to March 2022 were selected as the research objects.The levels of serum miR-124 and miR-221 were detected before treatment,4,8 and 12 weeks after treatment,and the non-motor symptoms of patients were evaluated by non-motor symptom evaluation scale(NMSs).Statistical methods were used to test and analyze the correlation between serum miR-124,miR-221 and NMSs score of Parkinson's patients.Results During the treatment,the serum miR-124 of the patients gradually increased,and the difference was statistically significant(P<0.05).The expression level of miR-221 and NMSs score decreased gradually,and the difference was statistically significant(P<0.05).Pearson correlation analysis showed that serum Mir-124 was negatively correlated with NMSs score(r=-0.346,P=0.001).MiR-221 was positively correlated with NMSs score(r=0.246,P<0.001).Linear regression analysis showed that the linear regression equation of serum miR-124 and miR-221 was y=39.713-6.706x1+1.47x2.The expression levels of miR-124 and miR-221 in serum of PD patients were the influencing factors of non-exercise symptoms(P<0.05).Conclusion The expression levels of serum miR-124 and miR-221 in PD patients are closely related to the severity of non-exercise symptoms.Clinically,it can be considered to monitor or intervene the expression levels of serum miR-124 and miR-221 to alleviate the non-exercise symptoms of PD patients and improve the prognosis of patients.
Parkinson's diseaseMicrorna-124Microrna-221Non motor symptoms
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