Objective To explore the correlation between late gadolinium enhancement-MRI and serum HA,AngⅡ,NT-proBNP in asymptomatic myocardial fibrosis with systemic sclerosis.Methods From January 2017 to July 2022,72 patients with symptomatic myocardial fibrosis with systemic sclerosis admitted to our hospital were selected as the observation group,and 50 patients with simple systemic sclerosis were selected as the control group at the same time.All patients underwent myocardial late gadolinium enhancement(LGE)scanning,and serum HA,AngⅡ,NT-proBNP levels were detected.Qualitative analysis(LGE negative,LGE positive)and quantitative analysis(LGE score)were performed on the myocardial segments examined by LGE.The levels of serum HA,AngⅡ,NT-proBNP were compared between the two groups,and the correlation between LGE score and serum HA,AngⅡ,NT-proBNP was analyzed.Results The levels of serum HA[(187.15±43.25)VS.(117.36±38.81)],Ang Ⅱ[(4357.71±977.31)VS.(3616.59±705.42)]and NT proBNP[(174.51±46.37)VS.(136.55±40.06)]in the observation group were significantly higher than those in the control group(P<0.05).The number of LGE positive segments and LGE score in the observation group were significantly higher than those in the control group(P<0.05).Serum HA,AngⅡ,NT-proBNP levels in patients with LGE positive segments≥6 were significantly higher than those in patients with LGE positive segments<6 and patients with LGE negative segments(P<0.05).Pearson test analysis showed that LGE score was positively correlated with HA(r=0.456,P<0.001),AngⅡ(r=0.384,P=0.001),NT-proBNP(r=0.299,P=0.011).The curve analysis showed that HA(AUC=0.760,95%CI:0.658～0.861).AngⅡ(AUC=0.773,95%CI:0.684～0.862),NT-proBNP(AUC=0.834,95%CI:0.755～0.913)had significant diagnostic value for silent myocardial fibrosis in systemic sclerosis(P<0.001).Conclusion The increase of serum HA,Ang Ⅱ,NT proBNP in patients with systemic sclerosis may be related to myocardial fibrosis,which can be used as an effective indicator to evaluate the degree of myocardial fibrosis.
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