Objective To investigate whether circulating levels of intestinal fatty-acid-binding proteins(IFABP)are associated with mortality in patients with cardiogenic shock in intensive care unit(ICU)admission.Methods 99 patients with cardiogenic shock in the ICU from January 2020 to May 2022 were selected.Serum levels of IFABP was measured within 24 hours after admission and at day 3.The patients were divided into a survival group(62 cases)and a death group(37 cases)according to the survival situation on the 28th day.The difference of IFABP concentration between the two groups and its effect on survival prognosis were analyzed.Results 62 patients with cardiogenic shock survived in 28 d,and the survival rate was 62.6%.The APAECH Ⅱ score and SOFA score of the survival group were significantly lower than those of the death group,and the proportion of ventilator use and vasoactive drugs was lower than that of the death group,with significant statistical significance.The serum IFABP concentration in the survival group was lower than that in the death group at 24 hours and 3 days after ICU admission,and there was a significant correlation at each time point(P<0.05).Logistic regression analysis showed that Serum levels of IFABP within 24 hours,APACHE Ⅱ score and SOFA score were risk factors for 28d mortality in patients with cardiogenic shock(P<0.05).IFABP showed a higher prognostic value for patients with cardiogenic shock,with sensitivity and specificity of 83.8%and 61.3%.Conclusion Circulating levels of IFABP provide evidence for predicting 28-day survival in patients with cardiogenic shock in intensive care unit.The increased levels of IFABP concentration may be associated with a dramatically decreased survival in patients with cardiogenic shock.
Fatty-acid-binding proteinsCardiogenic shockIntestinal perfusionCardiac outputIntensive care unit
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