精神分裂症患者血清尿酸和认知功能的相关性分析
郑克 1潘安乐 1吕伟 1潘建设 1叶晓丹 1刘家洪 1陈楚楚 1朱程2
作者信息
- 1. 325000 温州医科大学附属康宁医院
- 2. 310053 浙江中医药大学
- 折叠
摘要
目的 观察精神分裂症患者血清尿酸的变化,探讨及其与认知功能的相关性.方法 采用重复性成套神经心理状态监测量表(RBANS)评估71例精神分裂症患者(分裂症组)和37例性别及年龄匹配的健康者(对照组)的认知功能,同时采用尿酸酶-过氧化物法检测所有受试者的血清尿酸水平.结果 将性别、年龄、文化程度和BMI作为协变量控制后,分裂症组血清尿酸、即刻记忆、注意、言语、延迟记忆和RBANS总分均低于对照组(P<0.05).相关性分析发现分裂症组血清尿酸水平与即刻记忆和注意存在相关性(P<0.001);多元线性回归方程显示分裂症组血清尿酸与即刻记忆和注意存在正相关(P<0.05).结论 精神分裂症患者血清尿酸下降可能参与认知损伤的病理过程.
Abstract
Objective To investigate the changes in serum uric acid(UC)levels in patients with schizophrenia and explore its correlation with cognitive function Methods A total of 71 schizophrenia patients and 37 healthy controls were recruited.Cognitive functions were measured by the Repeatable Battery for the Assessment of Neuropsychological(RBANS),and serum UC levels were also estimated.Results The patients with schizophrenia had significantly lower scores on the nearly all of RBANS(i.e.,immediate memory,language,attention,delayed memory,and total score of RBANS)and serum UC levels than healthy controls after adjusting for variables(P<0.05).Pearson's correlation analyses showed that serum UC levels were positively associated with immediately memory and attention scores in schizophrenic patient(P<0.001).Furthermore,multivariate regression analyses showed that serum UC levels were positively associated with immediately memory and attention(P<0.05).Conclusion Reduced serum UC levels might be implicated in the pathophyology of cognitive impairments in schizophrenia.
关键词
尿酸/精神分裂症/认知功能Key words
Uric acid levels/Schizophrenia/Cognitive functions引用本文复制引用
基金项目
温州市基础性公益科研项目(Y20220839)
出版年
2024
NETL
NSTL
万方数据