首页|超声心动图结合肌钙蛋白及乳酸脱氢酶评估COVID-19合并心肌损伤重症患者的预后价值

超声心动图结合肌钙蛋白及乳酸脱氢酶评估COVID-19合并心肌损伤重症患者的预后价值

扫码查看
目的 比较超声心动图左室射血分数、肌钙蛋白、乳酸脱氢酶单个因素及互相组合模型评估新型冠状病毒感染(COVID-19)合并心肌损伤重症患者预后价值。方法 回顾性分析2022年12月至2023年1月COVID-19合并心肌损伤重症患者的临床资料,比较超声心动图左室射血分数、肌钙蛋白、乳酸脱氢酶评估COVID-19合并心肌损伤重症患者的预后效能。结果 44例COVID-19合并心肌损伤重症患者,18例死亡,26例预后为好转。经过二元Logistic分析筛选出左室射血分数分类、乳酸脱氢酶对患者预后评估为独立相关因素(P<0。05),同时加入肌钙蛋白建立两两联合以及三者联合模型,评估患者预后相关性的ROC曲线下面积分别为0。776、0。902、0。904、0。917。左室射血分数联合乳酸脱氢酶与左室射血分数联合肌钙蛋白及乳酸脱氢酶(P=0。264),肌钙蛋白联合乳酸脱氢酶与左室射血分数联合肌钙蛋白及乳酸脱氢酶(P=0。499),左室射血分数联合肌钙蛋白与左室射血分数联合肌钙蛋白及乳酸脱氢酶(P=0。022)。结论 超声心动图左室射血分数、肌钙蛋白、乳酸脱氢酶单个因素及互相组合模型对COVID-19合并心肌损伤重症患者预后评估均有价值,以三者联合模型对COVID-19合并心肌损伤重症患者预后评估价值最显著。
Objective To evaluate the prognosis of patients with novel coronavirus infection and myocardial injury by comparing the prognostic efficacy of echocardiography left ventricular ejection fraction,troponin,lactate dehydrogenase and their combination models.Methods The clinical data of patients with severe myocardial injury caused by novel coronavirus infection from December 2022 to January 2023 were retrospectively analyzed.The prognostic efficacy of patients with severe myocardial injury caused by novel coronavirus infection was evaluated by comparing the left ventricular ejection fraction,troponin and lactate dehydrogenase of echocardiography.Results 44 severe cases of novel coronavirus infection combined with myocardial injury were analyzed,of which 18 cases had a final prognosis of death and 26 cases had a final prognosis of improvement.After binary logistic analysis,left ventricular ejection fraction classification and lactate dehydrogenase were selected as independent related factors for the prognosis evaluation of patients(P<0.05).At the same time,troponin was added to establish a combination of two and three models according to the clinical requirements.The area under the ROC curve for the evaluation of patients'prognosis correlation was 0.776,0.902,0.904 and 0.917,respectively.Left ventricular ejection fraction combined with lactate dehydrogenase and left ventricular ejection fraction combined with troponin and lactate dehydrogenase(P=0.264),troponin combined with lactate dehydrogenase and left ventricular ejection fraction combined with troponin and lactate dehydrogenase(P=0.499),left ventricular ejection fraction combined with troponin and left ventricular ejection fraction combined with troponin and lactate dehydrogenase(P=0.022).Conclusion Echocardiographic left ventricular ejection fraction,troponin,lactate dehydrogenase and their combination models are all valuable for the prognosis evaluation of patients with novel coronavirus infection and myocardial injury.Among which the combination model of the three is the most significant for the prognosis evaluation of patients with novel coronavirus infection and myocardial injury.

Novel coronavirus infectionMyocardial injuryEchocardiogram

陈江涛、周一波、徐磊、徐恒

展开 >

321000 浙江省金华市中心医院

新型冠状病毒感染 心肌损伤 超声心动图

金华市COVID-19肺炎疫情应急防治科研攻关项目金华市科技局公益类项目

2020XG-052019-4-017

2024

浙江临床医学
浙江中医药大学 浙江省科普作家协会医学卫生委员会

浙江临床医学

影响因子:0.52
ISSN:1008-7664
年,卷(期):2024.26(6)
  • 15