Objective To observe the changes of intestinal microbiota in patients with hyperuricemia and analyze the correlation between hyperuricemia and renal damage.Methods This study collected 20 patients with hyperuricemia(HUA group)and 20 patients with uric acid nephropathy(HN group)who visited Tongde Hospital in Zhejiang Province from June 2022 to December 2022,as well as 20 healthy individuals of the same age group as the healthy control group(NC group).At the same time,their feces and blood samples were collected for analysis using 16S rRNA sequencing technology,and blood samples were used to measure clinical indicators such as kidney function.Results There were overall differences in intestinal flora among the three groups,among which there were significant differences in Alpha diversity analysis and Beta diversity analysis between the HUA group and the HN group.And in terms of microbial composition,the differences were mainly reflected in the phyla Acidobacteria,Verrucota,Nitrospira,Chlorobacterium,Erysiomycota,and Bacillus δ-Proteobacteria,Erythromida,Lactobacillus,Erythromida family.There was a correlation between patients with simple hyperuricemia and uric acid nephropathy and uric acid value,blood creatinine,urea nitrogen,and glomerular filtration rate(eGFR).Conclusion Compared with healthy individuals,individuals with hyperuricemia and uric acid nephropathy have dysbiosis in their gut microbiota,among which individuals with simple hyperuricemia and uric acid nephropathy each have unique gut microbiota characteristics.There is a correlation between gut microbiota and clinical indicators in patients with simple hyperuricemia and uric acid nephropathy.
Gut microbiotaHyperuricemiaUric acid nephropathy16S rRNAClinical indicators
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