Objective To explore the therapeutic effect of constraint induced aphasia therapy combined with high-frequency repetitive transcranial magnetic stimulation on post-stroke motor aphasia.Methods 80 stroke patients with motor aphasia from May 2019 to May 2021 were randomly divided into the control group and the observation group(40 cases in each group).The observation group received constraint induced aphasia therapy combined with high-frequency repetitive transcranial magnetic stimulation,while the control group received constraint induced aphasia therapy combined with transcranial magnetic pseudo-stimulation.The score of China rehabilitation research center aphasia examination(CRRCAE)and communication ability in daily living(CDAL)were recorded in the two groups before and after the treatment.The changes of serum brain-derived neurotrophic factor(BDNF)and glial-derived neurotrophic factor(GDNF)levels were contrasted in the two groups before and after the treatment.Results Before the treatment,there was no significant difference in the scores of CRRCAE and CDAL between the two groups(P>0.05),the scores of CRRCAE and CDAL were higher than the control group after treatment,and the difference was significant(P<0.05).Before the treatment,there was no significant difference in the scores of BDNF and GDNF between two groups(P>0.05),the scores of BDNF and GDNF were higher in observation group,and the difference was significant(P<0.05).Conclusion Constraint induced aphasia therapy combined with high-frequency repetitive transcranial magnetic stimulation can better improve the speech function of stroke patients with motor aphasia,and its mechanism may be related to the promotion of BDNF and GDNF expression.
High-frequency repetitive transcranial magnetic stimulationConstraint induced aphasia therapyStrokeMotor aphasia
万方数据
维普
