Objective To observe of the clinical efficacy of laparoscopic combined with transanal laparoscopic technique used in radical surgery for low rectal cancer.Methods A retrospective analysis of a total of 84 patients undergoing surgery for low rectal cancer from June 2019 to June 2022 in our hospital was selected and divided into the laparoscopy group and the combined endoscopic group with 42 cases respectively according to different operation methods.All low rectal carcinoma patients separately by laparoscopy and TaTME of total mechanical resection(TME).All patients underwent protective ileostomy.The relevant clinical indicators of the two groups(surgical indicators,surgical collateral injury,body stress response,postoperative intestinal function recovery time,recent complications,tumor pathology indicators,hospital stay,hospital cost,anal function,postoperative local recurrence and distant metastasis)were compared between the two groups.Results The conclusion showed that the combined endoscopic group had significant advantages over the laparoscopy group in terms of operation time,body stress response,postoperative intestinal function recovery time,hospital stay and cost,and the differences were statistically significant(P<0.05).Conclusion TaTME is safe,feasible and meets the requirements of TME surgery for low rectal cancer.It has advantages in operation time,surgical stress response,hospital stay and cost,and accelerates the recovery of patients and reduces medical costs.