Objective To explore the relationship between hydrosalpinx and endometrial lesions.Methods Retrospective analysis of clinical and pathological data of patients who underwent diagnostic curettage at Jiaxing Maternity and Child Health Care Hospital from January 2013 to December 2022 was conducted.They were divided into the normal endometrium group and the endometrial lesion group according to pathological types.The relationship between hydrosalpinx and endometrial lesions were analyzed.Results The results of univariate analysis showed that endometrial lesions were related to age,reproductive history,educational level,intrauterine contraceptive device,years of placement,menopause,years of menopause,and hydrosalpinx.The results of Logistic regression analysis showed that age≥60 years old and hydrosalpinx were high-risk factors for endometrial lesions in patients.Conclusion Hydrosalpinx is a high-risk factor for endometrial lesions,and patients with hydrosalpinx should strengthen screening and scientific education.