Objective To investigate the therapeutic effect of black garlic polyphenols in combination with western medicine on patients diagnosed with early-stage Alzheimer's disease(AD).Methods 120 patients with early AD admitted to our hospital from March 2019 to March 2020 were selected and randomly divided into an observation group and a control group,60 cases each,who received black garlic polyphenols combined with donepezil and donepezil monotherapy for 12 weeks,respectively.Before and after the treatment,the cognitive function,daily living ability and mental status of the patients in each group were evaluated by using the Brief Mental State Examination Scale(MMSE),Hasegawa Dementia Scale(HDS),Brief Psychiatric Rating Scale(BPRS),etc.Meanwhile,the activities of serum superoxide dismutase(SOD),glutathione peroxidase(GSH-PX),and malondialdehyde(MDA)were measured.levels,and adverse effects during treatment were recorded.Results The treatment efficiency of the observation group was 80.00%,and that of the control group was 61.67%,and the difference in the total efficiency between the two groups was statistically significant(P<0.05).The MMSE scores and HDS scores of the observation group were significantly higher than those of the control group,whereas the ADL scores and BPRS scores were significantly lower than those of the control group after the treatment(P<0.05),and the activities of serum SOD and GSH-PX were significantly elevated(P<0.05),and MDA levels were significantly decreased(P<0.05).Conclusion Black garlic polyphenols combined with donepezil have significant efficacy in treating patients with early AD,slowing cognitive decline and improving psychobehavioral symptoms.
Black garlic polyphenolsAlzheimer diseaseDonepezilOxidative stress
万方数据
维普
