Objective To explore the value of pain threshold index(PTI),index of consciousness2(IoC2)and surgical pleth index(SPI)in monitoring the depth of analgesia in general anesthesia patients.Methods Ninety patients undergoing elective laparoscopic cholecystectomy were selected and divided into IoC2 group(Group A),SPI group(Group B),and PTI group(Group C)according to different analgesic depth monitoring indexes by the block group randomization method.Heart rate(HR),mean pressure(MAP),IoC2,SPI and PTI of patients at each time point were recorded and compared,and the levels of serum inflammatory factors(IL-6,IL-10)were measured and compared before,during and after surgery.Results Comparison of IoC2,SPI,and PTI at T2 with T1(P<0.001).Comparison of SPI and PTI at T3 with T2(P<0.05).Comparison of PTI and SPI at T4 with T3(P<0.05).Comparison of IoC2 at T4 with T2 and T3(P<0.001).Comparison between SPI and PTI at T6 and T5(P<0.05).Comparison of IoC2,SPI,PTI at T7 and T5(P<0.05).Compare IoC2,SPI,and PTI at T8 with those at T7(P<0.05).Comparing within each group,IoC2,SPI and PTI had a time trend and all changed with different time points(P<0.001).Comparison among the three groups,HR,MAP,IoC2,SPI and PTI had unequal trends(P<0.001).IoC2,SPI and PTI were positively correlated with HR and MAP(P<0.05).There was no statistically significant difference between preoperative,intraoperative and postoperative comparisons of IL-6 and IL-10 in the three groups(P>0.05).Conclusion IoC2,PTI and SPI can be used as reliable indicators for intraoperative pain monitoring in general anesthesia to alleviate intraoperative stress reactions,with better accuracy than HR and MAP.
Depth of analgesiaIndex of consciousness2Surgical Pleth IndexPain Threshold indexGeneral anaesthesia
万方数据
维普
