Objective To investigate the application effect of goal-directed fluid therapy under the guidance of inferior vena cava variation combined with stroke volume variation(SVV)in the anesthesia management of patients undergoing laparoscopic radical resection of colorectal cancer.Methods 60 patients undergoing elective laparoscopic radical resection of colorectal cancer from July 2021 to June 2022 were selected and divided into 30 cases each in the conventional fluid rehydration group(group C)and SVV group(group S)according to different goal-directed fluid therapy.The intraoperative fluid intake and outflow,hemodynamics and optic Nerve Sheath Diameter(ONSD)at different time points,preoperative and operative laboratory indicators[C-reactive protein(CRP),variation of inferior vena cava,fibrinogen(FIB),plasma thromboxane B2(TXB2)]levels,preoperative and operative 1 and 3 d cognitive function were compared between the two groups.Results The total intake and colloid content in group S were significantly lower than those in group C(P<0.05),and there was no statistically significant difference in crystal content between the two groups(P>0.05).The difference in haemodynamics and ONSD between the two groups at some time points was statistically significant(P<0.05).The differences in the levels of laboratory indexes between preoperative and 1 d postoperative were statistically significant,and the variation of inferior vena cava was lower than before surgery.While the levels of CRP and FIB in group S were lower than those in the group C,and the variation of inferior vena cava was higher than that in group C(P<0.05).There was no statistically significant difference in cognitive function between the two groups before operation and 3 days after operation(P>0.05),and the cognitive function scores 1 d after the operation in group S were higher than those in group C(P<0.05).Conclusion The application of goal-directed fluid therapy under the guidance of inferior vena cava variation combined with SVV in the anesthesia management of patients undergoing laparoscopic radical resection of colorectal cancer can optimize intraoperative fluid management,reduce surgical stress,maintain the stability of the patient's internal environment,and reduce the degree of short-term cognitive impairment,and is beneficial to the postoperative rehabilitation of patients.
万方数据
维普
