Objective To study the feasibility of two-generation dual-source CT with high-pitch and low tube voltage combined iterative reconstruction in low-dose examination of cervical spine.Methods 60 patients with cervical pain investigated by cervical spine CT were prospectively into two groups.The first 30 patients were included in the observation group:tube voltage 100 kV,pitch 2.5,iterative reconstruction.The last 30 patients were included in the control group:tube voltage 120 kv,pitch 1.0,filtered reconstruction.The difference of radiation dose and image quality between the two groups was compared.Results The differences in CT volumetric dose index,radiation dose length product,and effective radiation dose between the two groups were statistically significant(P<0.001).The differences in signal-to-noise ratios of the spinal cord and C2 vertebrae in the C6~7 disc plane between the two groups were statistically significant(P<0.05).The image quality scores of both groups met the diagnostic requirements,and the C6~7 intervertebral disc image quality score of the low-dose group was higher than that of the standard-dose group(P<0.05).Conclusion The application of two-generation dual-source CT with high-pitch and low tube voltage in cervical CT scan can significantly reduce the radiation dose and obtain images that meet the diagnostic requirements,and can be used for cervical CT low-dose examination.