Objective To explore the correlation between strong ion gap(SIG)and the prognosis of sepsis patients during ICU hospitalization,aiming to improve the outcomes of patients.Methods The clinical data of 8963 adult sepsis patients admitted to ICU in the American Intensive Care Database(MIMIC-IV)from 2008 to 2019 were retrospectively analyzed,and the study population were divided into the survival group and the death group based on the prognosis during hospitalization.The association between SIG and the risk of ICU all-cause mortality and the prognosis of patients with sepsis and determine the optimal cut-off value of SIG were analyzed.Results The difference between the general information such as age,sequential organ failure assessment(SOFA)score,acute physiology score Ⅲ(APS Ⅲ),SIG in the two groups were statistically significant(P<0.05).RCS showed that there was a linear trend relationship between SIG and the risk of ICU all-cause mortality in patients with sepsis.COX regression analysis showed that high SIG(≥5.091 mmol/L)was an independent risk factor for all-cause mortality during hospitalization(HR=1.227,95％CI:1.094～1.377,P<0.05).Conclusion Elevated strong ion gap value(≥5.091 mmol/L)is an independent risk factor for increased ICU all-cause mortality in patients with sepsis.
Strong ion gapSepsisPrognosisCorrelation studyMIMIC-IV database
万方数据
维普
