Objective To evaluate the clinical effectiveness of combining acupuncture with hyperbaric oxygen therapy in the management of post-stroke cognitive impairment(PSCI).Methods A total of sixty patients diagnosed with PSCI were randomly assigned to four groups:the control group(n=15),the acupuncture group(n=15),the hyperbaric oxygen group(n=15),and the acupuncture+hyperbaric oxygen group(n=15).Prior to enrollment,all patients in the four groups had undergone conventional drug treatment and standard rehabilitation training.The acupuncture group received additional Xingnao Kaiqiao acupuncture treatment five times per week,with each session lasting 30 minutes.The hyperbaric oxygen group underwent hyperbaric oxygen therapy at a pressure of 0.1 MPa,with decompression lasting 20 minutes followed by stabilization at the pressure for 60 minutes,five times per week.The acupuncture+hyperbaric oxygen group received Xingnao Kaiqiao acupuncture and hyperbaric oxygen therapy for 4 weeks.Over a period of four weeks,four groups received treatment.Post-treatment assessments were conducted using the Montreal Cognitive Assessment Scale(MoCA),Mini-Mental State Examination(MMSE),and modified Barthel index.Results The results indicated that the MoCA score,MMSE score,and modified Barthel index of the acupuncture+hyperbaric oxygen group exhibited statistically significant improvements compared to the control group(P<0.001).Furthermore,the modified Barthel index of the acupuncture+hyperbaric oxygen group showed significantly greater improvement compared to both the acupuncture group and the hyperbaric oxygen group(P<0.05).Conclusion The integration of acupuncture and hyperbaric oxygen therapy has shown promising results in enhancing cognitive function and daily living capabilities among patients with PSCI.