Objective To investigate the classification of proteinuria and its risk factors in type 2 diabetes patients.Methods A retrospective analysis was conducted on the clinical data of 517 patients with type 2 diabetes from January 2023 to August 2023.Patients were divided into groups based on the urine albumin-to-creatinine ratio(ACR)and urine α1-microglobulin-to-creatinine ratio(MCR):non-proteinuria and proteinuria.The types of proteinuria were categorized as mixed,glomerular,and tubular.Results Mixed proteinuria was the most common type.Patients with a diabetic duration of over 10 years had the highest proportion of mixed proteinuria.The proportion of tubular proteinuria was lower in female patients compared to males(P<0.05).A history of alcohol consumption influenced proteinuria outcomes(P<0.001).Mixed proteinuria was more prevalent in patients over 60 years old compared to those under 60(P<0.001).The glomerular proteinuria was higher in patients taking ACEI/ARB medication than in those not taking it(P=0.019).In multivariate logistic regression analysis,the risk of mixed proteinuria was highest in patients with a diabetic duration of over 10 years(OR=2.46,95%CI:1.51～3.87,P=0.001).Age and gender were identified as independent risk factors for both glomerular and tubular proteinuria.Male patients had a lower risk of glomerular proteinuria than females(OR=0.71,P=0.009),but a higher risk of tubular proteinuria(OR=1.65,P=0.001).Systolic blood pressure was associated only with the risk of glomerular proteinuria(OR=1.02,P=0.021),while HbA1c was associated with the risk of both mixed and tubular proteinuria(P<0.001).Conclusion Mixed proteinuria was more common in patients with a diabetic duration of over 10 years,and that gender,age,and HbA1c levels were independent risk factors influencing the types of proteinuria.This suggested the importance of targeted risk assessment and individualized management in preventing diabetic kidney injury.
Type 2 diabetesGlomerular damageTubular damageType of proteinuriaRisk factors
万方数据
维普
