Objective To identify the association between the expression of EGFR,HER2 and VEGF in patients with gastric cancer and the efficacy of SOX regimen performed after surgery.Methods Select 142 gastric cancer patients from 2017 to 2019,measure the expression levels of EGFR,HER2,and VEGF in their gastric cancer tissues,and plot their survival curves after SOX chemotherapy regimen.Results Among the 142 patients,EGFR,HER2,and VEGF were positively expressed in 34 cases(24％),44 cases(31％),and 100 cases(70％),respectively.Univariate analysis showed that the positive expression of EGFR was related to differentiation degree,Lauren classification,preoperative CA19-9 and CEA levels.The positive expression of HER2 was related to gender,clinical stage,and Lauren classification.The positive expression of VEGF was related to age and vascular invasion.Multivariate analysis showed that Lauren's diffuse type and preoperative high levels of CA19-9 and CEA were independent risk factors for EGFR overexpression.Male and stage Ⅲ+Ⅳ,as well as Lauren's diffuse subtype,were independent risk factors for HER2 overexpression.Vascular invasion could increase the expression of VEGF.Conclusion The high expression of EGFR and HER2 in gastric cancer tissue is associated with the efficacy of SOX chemotherapy regimen.
万方数据
维普
