Objective To investigate the correlation between peripheral blood lymphocyte subsets and distal diffusion-weighted imaging(DWI)hyperintensity lesions after intracerebral hemorrhage(ICH).Methods A total of 203 patients with ICH were enrolled,basic information was collected,peripheral blood lymphocyte subsets and other laboratory indicators were analyzed,and the patients were divided into two groups according to the presence of DWI hyperintensity in distant sites combined with imaging data.Among them,161 cases without DWI hyperintensity lesions and 42 cases with DWI hyperintensity lesions were compared,and the general clinical characteristics of the two groups were compared.The correlation between the two was evaluated by logistic regression model.Results 42 patients(20.69％)had distant DWI high signal lesions.Patients with distant DWI hyperintensities had higher cerebral small vessel disease burden,total NK cells,T helper cells,and T helper/T suppressor cell ratio in peripheral blood lymphocyte subsets compared to patients without DWI hyperintensities.Logistic regression analysis showed that cerebral small vessel disease burden,total NK cells,and T helper/T suppressor cell ratio were independently correlated with distant DWI hyperintensities after ICH(P＜0.05).The optimal cutoff values determined by receiver operating characteristic(ROC)curves were 3 points,21.6％,and 1.75,respectively.Conclusion The total NK cells and the ratio of T-helper/T inhibitory cells in peripheral blood in patients with ICH are independent risk factors for DWI hyperintensity in distal sites after ICH.
万方数据
维普
