Objective To investigate the clinical characteristics,drug resistance,and BRO gene characteristics of Moraxella catarrhalis infection in children.Methods The clinical characteristics of children diagnosed with M.catarrhalis infection in the hospital between January 2020 and December 2022 were retrospectively analyzed.The drug resistance results of the isolated and cultured M.catarrhalis strains were also examined.Furthermore,the characteristics of the BRO gene in the strains were studied using PCR combined with restriction endonuclease enzyme analysis method.Data processing and analysis were conducted using WHONET 5.6 software,and statistical analysis was performed using SPSS23.0.Results Among the 531 strains of M.catarrhalis,a higher proportion was observed in infants aged 29 days to June(33.15％)and preschool children aged＞3 to 6 years old(29.76％).The occurrence of these strains was more common in autumn(September to November)and winter(December to February),accounting for 37.48％and 36.53％respectively.These differences were statistically significant(P＜0.01).All 531 strains of M.catarrhalis tested positive for β-lactamase.The insensitivity rate of sulfamethoxazole was high(75.14％),while no resistance was found to amoxicillin/clavulanic acid and cefotaxime.Among the strains,478 were identified as BRO-1 strains,while 53 were BRO-2 strains.The insensitivity rates of cefuroxime and cefaclor were higher in BRO-1 strains(82.64％and 79.92％respectively)compared to BRO-2 strains(5.67％and 5.67％).These differences were statistically significant(P＜0.01).Conclusion Preschool children between the ages of 3 and 6 are more susceptible to M.catarrhalis infection during the autumn and winter months,specifically from September to November and December to February.The primary type of infection during this time is BRO-1.It is important to note that BRO-1 strains exhibit a higher resistance to β-lactam antibiotics compared to BRO-2 strains.
万方数据
维普
