Objective To investigate the feasibility of optical coherence tomography angiography(OCTA)technique to detect retinal microvascular changes in patients with obstructive sleep apnea hypopnea syndrome(OSAHS).Methods Seventy-nine patients who were first diagnosed with OSAHS in our hospital from June 2023 to February 2024 and 25 age-matched healthy controls were selected.Polysomnography(PSG)examination and OCTA were performed on all participants.Patients were grouped according to their AHI scores,and retinal vascular density(VD)and central concave avascular zone(FAZ)were quantified.Results Vessel density of retinal microvascular plexus in patients with moderate and severe OSAHS was lower than that in the control group(P＜0.05),and the FAZ area was larger than that in the control group(P＜0.05).Pearson correlation analyses showed a weak correlation between the FAZ and the AHI score and LSaO2(r=0.271,P=0.026;r=-0.301,P=0.007).Conclusion OSAHS patients have decreased retinal microvessel density and enlarged FAZ compared with normal subjects,and it correlates with AHI score and LSaO2,and OCTA examination has a role in the pathological mechanisms and clinical management of OSAHS.
Obstructive sleep apnea hypopnea syndromeOptical coherence tomography angiographyRetinal blood vessel densityFovea without vascular area
万方数据
维普
