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脑室外引流术后感染的风险因素分析及列线图预测模型构建

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目的 探讨脑室外引流(EVD)术后感染的风险因素,并构建其列线图预测模型。方法 回顾性分析2020年6月至2022年7月100例接受EVD治疗患者的临床资料。根据EVD术后是否发生相关性感染分为感染组(n=18)和非感染组(n=82)。采用Logistic回归分析EVD术后感染的独立风险因素,并构建EVD术后发生相关性感染的列线图预测模型,采用受试者工作特征(ROC)曲线验证模型的预测效能。结果 两组患者颅内出血、合并其他系统感染、合并开颅手术、术前有人工气道、双侧置管、脑脊液取样频率≥3次/周、导管留置时间≥7 d、术后白蛋白≤35 g/L的占比以及ICU住院时间比较,差异有统计学意义(P<0。05)。Logistic回归分析合并其他系统感染、合并开颅手术、脑脊液取样频率>3次/周、导管留置时间>7 d及ICU住院时间长是EVD术后发生相关性感染的独立风险因素。EVD术后发生相关性感染列线图预测模型的AUC为0。894(95%CI:0。817~0。947),敏感性为72。00%,特异性为98。8%。结论 合并其他系统感染、合并开颅手术、脑脊液取样频率≥3次/周、导管留置时间>7 d及ICU住院时间长是EVD术后发生相关性感染的独立风险因素,依据以上因素构建的列线图模型具有较好的预测效能。
Objective To explore the risk factors of postoperative infection after external ventricular drainage(EVD)and to construct a nomogram prediction model.Methods The clinical data of 100 patients treated with EVD from June 2020 to July 2022 were retrospectively analysed.They were divided into the infected(n=18)and the non-infected(n=82)groups according to whether an associated infection occurred after EVD.Logistic regression was used to analyse the independent risk factors for post-EVD infections,and a nomogram prediction model was constructed for the occurrence of associated infections after EVD,and the predictive efficacy of the model was verified using the subject's work characteristics(ROC)curve.Results The percentages of patients with intracranial haemorrhage,combined other systemic infections,combined craniotomy,preoperative presence of an artificial airway,bilateral placement of tubes,cerebrospinal fluid sampling frequency≥3 times/week,catheter retention time≥7 d,and postoperative albumin≤35 g/L,as well as the length of stay in the ICU were compared between the two groups,and the differences were statistically significant(P<0.05).Logistic regression analysis of the percentage of patients with combined other systemic infections,combined craniotomy,cerebrospinal fluid sampling frequency>3 times/week,catheter reten-tion time>7 d,and long ICU hospital stay were independent risk factors for the occurrence of associated infections after EVD.The AUC of the column-line graph prediction model for the occurrence of associated infections after EVD was 0.894(95%CI:0.817~0.947),with a sensitivity of 72.00%and a specificity of 98.8%.Conclusion Combined with other systemic infections,combined with craniotomy,cerebrospinal fluid sampling frequency≥3 times/week,catheter retention time>7 d and long ICU stay are independent risk factors for the occurrence of associated infections after EVD,and the column chart model constructed based on the above factors has a good predictive efficacy.

External ventricular drainageInfectionRisk factorsNomogram model

孔成、杨帆

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322399 浙江省金华市中心医院磐安分院

321000 浙江省金华市中心医院

脑室外引流 感染 风险因素 列线图模型

2024

浙江临床医学
浙江中医药大学 浙江省科普作家协会医学卫生委员会

浙江临床医学

影响因子:0.52
ISSN:1008-7664
年,卷(期):2024.26(10)