Objective To investigate the optimal time window for reoperative intervention in endovascular treatment of arteriosclerosis obliterans of lower extremities.Methods A total of 256 patients with lower limb arterial occlusive disease(ASO)who underwent balloon angioplasty(PTA)and/or stent implantation(STENT)from September 2020 to June 2023 were selected as the study subjects.Among them,33 patients experienced moderate to severe stenosis(CTA measured inner diameter/normal inner diameter≤50%)or occlusion of the lower limb arteries 6 months after the first surgery.According to different treatment methods,patients were divided into the intervention group,the control group A,and the control group B.Among them,8 patients in the intervention group underwent reoperation mainly with PTA around 6 months(average 6.5 months)after surgery;18 cases in the control group A were treated with conservative medication.Seven patients in the control group B underwent reoperation between 12~28 months(average 20.3 months)after surgery.The arterial patency rate,surgical success rate,and total surgical cost of the three groups were compared at 12,18,24,and 30 months after the first surgery.Results The arterial patency rate of the intervention group at 18,24,and 30 months after surgery was higher than that of the two control groups,and the success rate of surgery was similar to that of the control group B.The target vessel was opened in a shorter time and the surgical cost was lower.Conclusion For patients with moderate to severe restenosis or occlusion after the first ASO surgery,performing endovascular treatment again 6 months after surgery has a high success rate and a high mid to long term arterial patency rate,making it the best time window for reoperation intervention.