Objective To explore the correlation between the degree of osteoporosis and chronic obstructive pulmonary disease(COPD)based on bone density levels.Methods 53 clinically stable male patients with COPD were selected as the study group,and 30 age-matched healthy males were selected as the control group.The research team classified the patients according to the Global Initiative for Chronic Obstructive Pulmonary Disease(GOLD)revised edition in 2023,and based on the results of bone mineral density(BMD)testing,divided them into the normal bone mass group,the reduced bone mass group,and the osteoporosis group.Analyze the correlation between BMD and lung function levels,disease duration,and serum levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-1 β(IL-1 β),and C-reactive protein(CRP)expression in the research group.Results There was a statistically significant difference(P＜0.05)in the BMD of the lumbar spine(L1～4),left femoral neck,and left hip joint between the research group and the control group with different GOLD grades.The correlation analysis results showed that lung function grading was significantly negatively correlated with the BMD T values of the lumbar spine,left hip joint,and left femoral neck(P＜0.05).There were statistically significant differences in body mass index(BMI),serum TNF-α,and CRP levels among different BMD groups(P＜0.05),and the differences were statistically significant among different disease courses and GOLD grades(P＜0.05).The correlation analysis results showed that the degree of osteoporosis in COPD patients was negatively correlated with BMI(P＜0.05),and positively correlated with IL-1 β,TNF-α,and CRP levels(P＜0.05).Conclusion Reduced BMD in COPD patients is associated with low BMI,long disease duration,high inflammation levels,and impaired lung function.
Chronic obstructive pulmonary diseaseOsteoporosisPulmonary functionBone mineral density
万方数据
维普
