Objective To explore a low-cost and systematic comprehensive treatment model to rapidly and effectively improve the severity of patients with obsessive-compulsive disorder(OCD).Methods 89 patients diagnosed with OCD were selected and divided into a medication treatment group of 64 cases and a comprehensive treatment group of 25 cases.They underwent a two-week transcranial direct current therapy(tDCS)+medication treatment+psychological treatment comprehensive group.Both before and after treatment were evaluated using the Yale-Brown Obsessive-Compulsive Scale(Y-BOCS),the 24 item Hamilton Depression Scale(HAMD-24),and the Hamilton Anxiety Scale(HAMA).Results After 2 weeks of treatment,the total score and factor score of Y-BOCS in both groups of patients decreased compared to before treatment(P＜0.05).The comprehensive treatment group had a lower Y-BOCS total score(Z=-3.112,P=0.002)and factor score(thinking score Z=-2.13,P=0.033)(behavior score Z=-3.334,P=0.001),HAMD total score(Z=-2.819,P=0.005),and HAMA total score(Z=-2.002,P=0.045)than the drug treatment group,and the Y-BOCS reduction rate was higher than that of the drug treatment group(Z=-3.658,P＜0.001).After 2 weeks,the effective rate of the comprehensive treatment group was higher than that of the drug treatment group(Z=11.063,P＜0.001).The total scores of HAMD and HAMA in both groups decreased compared to before treatment(P＜0.05).Conclusion The comprehensive treatment mode of tDCS can significantly improve the severity of OCD in patients in the short term.
Obsessive-compulsive disorderCombined therapeutic modalityCognitive behavioral therapyTranscranial direct current stimulation
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