Objective To explore the efficacy of unilateral double spinal endoscopy(UBE)and microscope-assisted(MIS)transforaminal lumbar intraspinal fusion(TLIF)for lumbar spinal stenosis.Methods The clinical treatment data of 58 patients with lumbar spinal stenosis admitted to Jiaxing No.1 Hospital from September 2020 to September 2022 were retrospectively analyzed,and they were divided into the UBE-TLIF group(25 cases)and the MIS-TILF group(33 cases)according to the surgical methods.The operation time,total perioperative blood loss,postoperative drainage,hospitalization time,Oswestry dysfunction index(ODI)and visual analog assessment of pain(VAS)during preoperative and postoperative follow-up at 3 months,6 months and one year,as well as the incidence of postoperative complications and the rate of interbody fusion were analyzed in different groups.Results The data showed no obvious difference in perioperative total blood loss,postoperative drainage,postoperative hemoglobin loss and hospitalization time data of the two groups(P>0.05),and the operation time of the MIS-TLIF group was obviously shorter than the UBE-TLIF group(P<0.05),while postoperative patients of the two groups could significantly improve the VAS scores of lumbar and leg pain and ODI indices,and the UBE-TLIF group showed a significant improvement in VAS scores of lumbar and leg pain at 3 postoperative days,and the UBE-TLIF group had an advantage over the MIS-TLIF group in the improvement of low back pain VAS score in 3 months after the operation(P<0.05),while the difference of these patients in leg pain VAS and ODI index at 3 months postoperatively was not statistically significant(P>0.05).At the follow-up from 6 months to 12 months postoperatively,the differences in the comparative data of low back pain VAS,leg pain VAS and ODI between the two groups of patients were not statistically significant(P>0.05).At 12 months postoperatively,the intervertebral fusion rate in the MIS-TILF group reached 97%,while that in the UBE-TLIF group was 92%(P>0.05).There is no significant difference in the incidence of postoperative complications among patients undergoing different surgeries(P>0.05).Conclusion Surgical modalities of UBE-TLIF and MIS-TLIF can obtain acceptable therapeutic effects to treat lumbar spinal stenosis.Although the operation time of UBE-TLIF is longer than that of MIS-TLIF,the trauma caused by this technology is smaller,and patients could recover in a shorter time,which is worthy of being popularized for use in the clinic.